Literature DB >> 11933126

Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity.

Chao-mei Ma1, Norio Nakamura, Hirotsugu Miyashiro, Masao Hattori, Katsuko Komatsu, Takuya Kawahata, Toru Otake.   

Abstract

Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 microg/mL, respectively. Copyright 2002 John Wiley & Sons, Ltd.

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Year:  2002        PMID： 11933126     DOI： 10.1002/ptr.922

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  6 in total

1.  Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi.

Authors:  Bharat P Bashyal; Brian P Wellensiek; Rajesh Ramakrishnan; Stanley H Faeth; Nafees Ahmad; A A Leslie Gunatilaka
Journal:  Bioorg Med Chem       Date:  2014-09-08       Impact factor: 3.641

2.  FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression.

Authors:  Hong De Xu; Soon-Chang Cho; Mi-Ae Bang; Chun-Sik Bae; Yeonshik Choi; Yong-Chun Li; Seung-Kil Lim; Jaegal Shim; Dae-Hun Park
Journal:  Int J Oncol       Date:  2015-03-27       Impact factor: 5.650

3.  6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.

Authors:  Yong-Chun Li; Bong-Hee Kim; Soon-Chang Cho; Mi-Ae Bang; Sunmin Kim; Dae-Hun Park
Journal:  Int J Oncol       Date:  2014-11-07       Impact factor: 5.650

4.  Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines.

Authors:  Shynggys Sergazy; Anastassiya Vetrova; Ilkay Erdogan Orhan; Fatma Sezer Senol Deniz; Ahmet Kahraman; Jian-Ye Zhang; Mohamad Aljofan
Journal:  Future Sci OA       Date:  2021-12-03

Review 5.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

6.  Phytotherapeutic options for the treatment of COVID-19: A concise viewpoint.

Authors:  Misbahud Din; Fawad Ali; Abdul Waris; Fatima Zia; Muhammad Ali
Journal:  Phytother Res       Date:  2020-08-20       Impact factor: 5.878
  6 in total

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