Literature DB >> 11932020

The sterol-sensing domain: multiple families, a unique role?

Patricia E Kuwabara1, Michel Labouesse.   

Abstract

The "sterol-sensing domain" (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.

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Year:  2002        PMID： 11932020     DOI： 10.1016/s0168-9525(02)02640-9

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  96 in total

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Authors:  R Kennedy Keller; Thomas P Arnold; Steven J Fliesler
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9.  Molecular consequences of altered neuronal cholesterol biosynthesis.

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10.  Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.

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