Jhansi R Raju1, David V Weinberg. 1. Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Abstract
PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection. DESIGN: Experimental laboratory investigation. METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance. RESULTS: The mean measured volume delivered was less than the intended volume for every syringe (P <.001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon. CONCLUSION: Clinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.
PURPOSE: To assess the accuracy and precision of methods in clinical use for intraocular drug injection. DESIGN: Experimental laboratory investigation. METHODS: A total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance. RESULTS: The mean measured volume delivered was less than the intended volume for every syringe (P <.001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon. CONCLUSION: Clinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.
Authors: Frank L Brodie; Jason Ruggiero; Devon H Ghodasra; Kian Eftekhari; James Z Hui; Alexander J Brucker; Brian L VanderBeek Journal: Curr Eye Res Date: 2013-11-20 Impact factor: 2.424