Michael M Lai1, Julia A Haller. 1. Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Abstract
PURPOSE: To report the effect of 5-fluorouracil on the outcome of a single case of epithelial ingrowth secondary to a wound leak after a complicated penetrating keratoplasty. DESIGN: Case report. METHODS: A 44-year-old man with extensive epithelial ingrowth after trauma and a penetrating keratoplasty received a fluid-gas exchange followed by two injections of 500 microg of 5-fluorouracil into the anterior chamber. RESULTS: Two weeks after receiving the 5-fluorouracil injections, complete disappearance of the epithelial ingrowth from the anterior chamber occurred. No evidence of recurrence was detectable at 5 months. CONCLUSION: Use of 5-fluorouracil is a potentially effective treatment of epithelial ingrowth, particularly in eyes with extensive involvement, in which the risks of traditional ablative therapeutic modalities are considerable.
PURPOSE: To report the effect of 5-fluorouracil on the outcome of a single case of epithelial ingrowth secondary to a wound leak after a complicated penetrating keratoplasty. DESIGN: Case report. METHODS: A 44-year-old man with extensive epithelial ingrowth after trauma and a penetrating keratoplasty received a fluid-gas exchange followed by two injections of 500 microg of 5-fluorouracil into the anterior chamber. RESULTS: Two weeks after receiving the 5-fluorouracil injections, complete disappearance of the epithelial ingrowth from the anterior chamber occurred. No evidence of recurrence was detectable at 5 months. CONCLUSION: Use of 5-fluorouracil is a potentially effective treatment of epithelial ingrowth, particularly in eyes with extensive involvement, in which the risks of traditional ablative therapeutic modalities are considerable.
Authors: Santiago Montolío-Marzo; Ester Fernández-López; Jose Vicente Piá-Ludeña; Juan María Davó-Cabrera; Enrique Antonio Alfonso-Muñoz; Cristina Peris-Martínez Journal: Int J Ophthalmol Date: 2020-05-18 Impact factor: 1.779
Authors: Nandini Venkateswaran; Steven S T Ching; William Fischer; Frank Lee; Gabrielle Yeaney; Holly B Hindman Journal: Case Rep Ophthalmol Med Date: 2015-08-12