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Literature DB >> 11931737

Prime movers of synaptic vesicle exocytosis.

Abstract

Chemical synapses contain specialized pre- and postsynaptic structures that underlie rapid synaptic transmission and its modulation. Studies of postsynaptic organization have revealed a network of interacting proteins that enable rapid synaptic responses and their modulation. Recent genetic and electrophysiological studies on two active zone proteins-RIM and Munc13-reveal important roles in priming vesicles for Ca(2+)-triggered fusion and in mediating the regulation of this process. This work sheds new light on how presynaptic structure provides speed and plasticity to synaptic transmission.

Entities: Chemical Gene

Mesh：

Year: 2002 PMID： 11931737 DOI： 10.1016/s0896-6273(02)00651-7

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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Cited

14 in total

Review 1. Regulation of vesicle traffic and neurotransmitter release in isolated nerve terminals.

Authors: Wim E J M Ghijsen; A G Miriam Leenders; Fernando H Lopes da Silva
Journal: Neurochem Res Date: 2003-10 Impact factor: 3.996

2. A highly Ca2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells.

Authors: Yan Yang; Sangeetha Udayasankar; James Dunning; Peng Chen; Kevin D Gillis
Journal: Proc Natl Acad Sci U S A Date: 2002-11-21 Impact factor: 11.205

3. ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy.

Authors: Mica Ohara-Imaizumi; Toshihisa Ohtsuka; Satsuki Matsushima; Yoshihiro Akimoto; Chiyono Nishiwaki; Yoko Nakamichi; Toshiteru Kikuta; Shintaro Nagai; Hayato Kawakami; Takashi Watanabe; Shinya Nagamatsu
Journal: Mol Biol Cell Date: 2005-05-11 Impact factor: 4.138

4. A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1.

Authors: M Michaelides; G E Holder; D M Hunt; F W Fitzke; A C Bird; A T Moore
Journal: Br J Ophthalmol Date: 2005-02 Impact factor: 4.638

Prime movers of synaptic vesicle exocytosis.

Review 1. Regulation of vesicle traffic and neurotransmitter release in isolated nerve terminals.

2. A highly Ca2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells.

3. ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy.

4. A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1.

5. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.

6. Calcium sensitivity of neurotransmitter release differs at phasic and tonic synapses.

7. Ca2+ dependency of 'Ca2+-independent' exocytosis in SPOC1 airway goblet cells.

8. Regulation of syntaxin1A-munc18 complex for SNARE pairing in HEK293 cells.

9. Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.

10. Rab27b regulates number and secretion of platelet dense granules.