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Literature DB >> 1193018

The mobilization of bone mineral by 1,25-dihydroxyvitamin D3 in hypophosphatemic rats.

Abstract

Administration of 1,25-dihydroxyvitamin D3 to thyroparathyroidectomized, hypophosphatemic rats on a low-phosphorus diet increases serum inorganic phosphorus and calcium concentrations. Experiments utilizing such rats treated with 45Ca and 32P ten days before use revealed that the rise in serum phosphorus in response in 1,25-dihydroxy-vitamin D3 is derived at least in part from bone mineral. This suggests that under conditions of hypophosphatemia, 1,25-dihydroxyvitamin D3 can mobilize bone in the absence of parathyroid hormone.

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Year: 1975 PMID： 1193018 DOI： 10.1210/endo-97-4-995

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736

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Cited

11 in total

1. Vitamin D metabolism and expression in rats fed on low-calcium and low-phosphorus diets.

Authors: S Edelstein; D Noff; L Sinai; A Harell; J B Puschett; E E Golub; F Bronner
Journal: Biochem J Date: 1978-02-15 Impact factor: 3.857

2. Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick.

Authors: B E Booth; H C Tsai; R C Morris
Journal: J Clin Invest Date: 1977-12 Impact factor: 14.808

7. Comparison of the effects of 1,25-dihydroxycholecalciferol, prostaglandin E2, and osteoclast-activating factor with parathyroid hormone on the ultrastructure of osteoclasts in cultured long bones of fetal rats.

Authors: M E Holtrop; L G Raisz
Journal: Calcif Tissue Int Date: 1979 Impact factor: 4.333

The mobilization of bone mineral by 1,25-dihydroxyvitamin D3 in hypophosphatemic rats.

1. Vitamin D metabolism and expression in rats fed on low-calcium and low-phosphorus diets.

2. Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick.

3. Interactions between vitamin D deficiency and phosphorus depletion in the rat.

4. 'Moderate' hypophosphatemia--not always an innocent bystander.

5. Role of vitamin D in maternal skeletal changes during pregnancy and lactation: a histomorphometric study.

6. Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyroparathyroidectomized rats.

7. Comparison of the effects of 1,25-dihydroxycholecalciferol, prostaglandin E2, and osteoclast-activating factor with parathyroid hormone on the ultrastructure of osteoclasts in cultured long bones of fetal rats.

8. Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3.

9. Relative effectiveness of vitamin D metabolites in increasing bone mineral solubility.

10. Vitamin D and hyperparathyroidism: the Lumleian Lecture 1981.