Literature DB >> 119295

The pharmacology of diclofenac sodium (Voltarol).

R Maier, R Menassé, L Riesterer, C Pericin, M Ruegg, R Ziel.   

Abstract

Diclofenac is a potent anti-inflammatory and analgesic compound with good antipyretic and uricosuric properties. It is one of the most potent inhibitors of prostaglandin synthetase known. It shows a favourable therapeutic ratio considering its efficacy, and proved superior to the reference drugs in terms of gastro-intestinal tolerability. All metabolites are clearly less potent than the parent compound.

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Year:  1979        PMID: 119295

Source DB:  PubMed          Journal:  Rheumatol Rehabil        ISSN: 0300-3396


  7 in total

1.  Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats.

Authors:  L Gelgor; N Butkow; D Mitchell
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

2.  Preemptive effects of a combination of preoperative diclofenac, butorphanol, and lidocaine on postoperative pain management following orthognathic surgery.

Authors:  C Nagatsuka; T Ichinohe; Y Kaneko
Journal:  Anesth Prog       Date:  2000

3.  Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries.

Authors:  Francisco Esparza; César Cobián; José Fernando Jiménez; Juan José García-Cota; Carlos Sánchez; Antonio Maestro
Journal:  Br J Sports Med       Date:  2006-11-30       Impact factor: 13.800

4.  Acute anti-inflammatory activity and gastrointestinal tolerability of diclofenac and nitrofenac.

Authors:  A Conforti; M Donini; G Brocco; P Del Soldato; G Benoni; L Cuzzolin
Journal:  Agents Actions       Date:  1993-11

Review 5.  Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Authors:  P A Todd; E M Sorkin
Journal:  Drugs       Date:  1988-03       Impact factor: 9.546

Review 6.  Diclofenac sodium injection (Dyloject): in postoperative pain.

Authors:  Paul L McCormack; Lesley J Scott
Journal:  Drugs       Date:  2008       Impact factor: 9.546

Review 7.  Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.

Authors:  R N Brogden; R C Heel; G E Pakes; T M Speight; G S Avery
Journal:  Drugs       Date:  1980-07       Impact factor: 9.546

  7 in total

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