BACKGROUND: An important characteristic of children with autism is their unusual reaction to stimuli, which may be related to problems in the filtering of sensory input. For this reason, sensory filtering was measured in children with autism using the P50 gating paradigm. METHOD: Twelve non-mentally retarded children with autism (i.e., having a DSM-IV diagnosis of either autistic disorder or pervasive developmental disorder not otherwise specified) and 11 healthy control children were tested for their ability to suppress P50, measured at the Cz electrode. RESULTS: No differences were found between the children with autism and the control children with regard to absolute P50 amplitudes and P50 suppression. CONCLUSION: The excitability of the neuronal substrate that causes P50 is normal in children with autism, as are the early, inhibitory processes related to P50 gating. These results distinguish between subjects with autism and subjects with schizophrenia, in whom sensory gating is abnormal.
BACKGROUND: An important characteristic of children with autism is their unusual reaction to stimuli, which may be related to problems in the filtering of sensory input. For this reason, sensory filtering was measured in children with autism using the P50 gating paradigm. METHOD: Twelve non-mentally retardedchildren with autism (i.e., having a DSM-IV diagnosis of either autistic disorder or pervasive developmental disorder not otherwise specified) and 11 healthy control children were tested for their ability to suppress P50, measured at the Cz electrode. RESULTS: No differences were found between the children with autism and the control children with regard to absolute P50 amplitudes and P50 suppression. CONCLUSION: The excitability of the neuronal substrate that causes P50 is normal in children with autism, as are the early, inhibitory processes related to P50 gating. These results distinguish between subjects with autism and subjects with schizophrenia, in whom sensory gating is abnormal.
Authors: Francisco J Ruiz-Martínez; Elena I Rodríguez-Martínez; C Ellie Wilson; Shu Yau; David Saldaña; Carlos M Gómez Journal: J Autism Dev Disord Date: 2020-02
Authors: Mehmet A Coskun; Katherine A Loveland; Deborah A Pearson; Andrew C Papanicolaou; Bhavin R Sheth Journal: Autism Res Date: 2013-08-27 Impact factor: 5.216
Authors: Jeffrey H Kogan; Adam K Gross; Robert E Featherstone; Rick Shin; Qian Chen; Carrie L Heusner; Megumi Adachi; Amy Lin; Noah M Walton; Sosuke Miyoshi; Shinichi Miyake; Katsunori Tajinda; Hiroyuki Ito; Steven J Siegel; Mitsuyuki Matsumoto Journal: J Neurosci Date: 2015-12-09 Impact factor: 6.167