LEARNING OBJECTIVES: This article reviews current concepts of the innate immune system that offers protection against infections. It offers an overview for the readers to understand how innate immunity, consisting of different receptors, cells, and mediators recognizes pathogens and exerts protective function against pathogens. DATA SOURCES AND STUDY SELECTION: MEDLINE-search articles including original research papers, review articles, textbooks, and references identified from bibliographies of relevant articles. RESULTS AND CONCLUSIONS: The innate immune system is nonspecific immunity present since birth not requiring repeated exposure to pathogens. It is capable of differentiation between self and nonself. Because of its nonspecificity, it has a broad spectrum of resistance to infection. Further, it is thought to play an important role in the control of adaptive immunity by regulating co-stimulatory molecules and effector cytokines. Innate immunity includes pattern recognition molecules/receptors, antimicrobial peptides, the complement system, inflammatory mediators, and cytokines produced by immune cells. Pattern recognition molecules/receptors recognize pathogen-associated molecular patterns that are essential for microorganisms' survival and pathogenicity. Although innate immunity has recently gained increasing importance, further studies are necessary for a better understanding of its role.
LEARNING OBJECTIVES: This article reviews current concepts of the innate immune system that offers protection against infections. It offers an overview for the readers to understand how innate immunity, consisting of different receptors, cells, and mediators recognizes pathogens and exerts protective function against pathogens. DATA SOURCES AND STUDY SELECTION: MEDLINE-search articles including original research papers, review articles, textbooks, and references identified from bibliographies of relevant articles. RESULTS AND CONCLUSIONS: The innate immune system is nonspecific immunity present since birth not requiring repeated exposure to pathogens. It is capable of differentiation between self and nonself. Because of its nonspecificity, it has a broad spectrum of resistance to infection. Further, it is thought to play an important role in the control of adaptive immunity by regulating co-stimulatory molecules and effector cytokines. Innate immunity includes pattern recognition molecules/receptors, antimicrobial peptides, the complement system, inflammatory mediators, and cytokines produced by immune cells. Pattern recognition molecules/receptors recognize pathogen-associated molecular patterns that are essential for microorganisms' survival and pathogenicity. Although innate immunity has recently gained increasing importance, further studies are necessary for a better understanding of its role.
Authors: Berthony Deslouches; Kazi Islam; Jodi K Craigo; Shruti M Paranjape; Ronald C Montelaro; Timothy A Mietzner Journal: Antimicrob Agents Chemother Date: 2005-08 Impact factor: 5.191
Authors: I Wong-Baeza; N González-Roldán; E Ferat-Osorio; N Esquivel-Callejas; R Aduna-Vicente; L Arriaga-Pizano; H Astudillo-de la Vega; M A Villasis-Keever; R Torres-González; I Estrada-García; C López-Macías; A Isibasi Journal: Clin Exp Immunol Date: 2006-09 Impact factor: 4.330
Authors: Angelo Mena; Anil K Nichani; Yurij Popowych; Dale L Godson; Donna Dent; Hugh G G Townsend; George K Mutwiri; Rolf Hecker; Lorne A Babiuk; Philip Griebel Journal: Immunology Date: 2003-10 Impact factor: 7.397
Authors: Patricia A Manderscheid; Ryan P Bodkin; Bruce A Davidson; Erik Jensen; Thomas A Russo; Paul R Knight Journal: Clin Diagn Lab Immunol Date: 2004-07
Authors: Bart Buitenhuis; Christine M Røntved; Stefan M Edwards; Klaus L Ingvartsen; Peter Sørensen Journal: BMC Genomics Date: 2011-02-28 Impact factor: 3.969