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Literature DB >> 11926317

Signaling and cell death in lymphocytes.

Abstract

After activation, CD4 helper T (Th) cells differentiate into Th1 or Th2 effector cells. These two subsets produce distinct profiles of cytokines and regulate different immune responses. Here we discuss transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression, cell proliferation and apoptosis.

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Year: 2002 PMID： 11926317 DOI： 10.1007/BF02684006

Source DB: PubMed Journal: Inflamm Res ISSN： 1023-3830 Impact factor: 4.575

27 in total

Review 1. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Authors: T R Mosmann; R L Coffman
Journal: Annu Rev Immunol Date: 1989 Impact factor: 28.527

2. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

Authors: D D Yang; D Conze; A J Whitmarsh; T Barrett; R J Davis; M Rincón; R A Flavell
Journal: Immunity Date: 1998-10 Impact factor: 31.745

3. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism.

Authors: W Ouyang; S H Ranganath; K Weindel; D Bhattacharya; T L Murphy; W C Sha; K M Murphy
Journal: Immunity Date: 1998-11 Impact factor: 31.745

4. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.

Authors: D H Zhang; L Yang; L Cohn; L Parkyn; R Homer; P Ray; A Ray
Journal: Immunity Date: 1999-10 Impact factor: 31.745

5. JNK is required for effector T-cell function but not for T-cell activation.

Authors: C Dong; D D Yang; C Tournier; A J Whitmarsh; J Xu; R J Davis; R A Flavell
Journal: Nature Date: 2000-05-04 Impact factor: 49.962

6. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.

Authors: D H Zhang; L Cohn; P Ray; K Bottomly; A Ray
Journal: J Biol Chem Date: 1997-08-22 Impact factor: 5.157

Signaling and cell death in lymphocytes.

Review 1. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

2. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

3. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism.

4. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.

5. JNK is required for effector T-cell function but not for T-cell activation.

6. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.

7. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.

8. Defective T cell differentiation in the absence of Jnk1.

9. Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation.

10. The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes.

1. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity.