OBJECTIVE: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. METHOD: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. RESULTS: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. CONCLUSIONS: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.
OBJECTIVE: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. METHOD: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. RESULTS:myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. CONCLUSIONS: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.
Authors: Raquelle I Mesholam-Gately; Anthony J Giuliano; Eric A Zillmer; Lamia P Barakat; Anand Kumar; Ruben C Gur; Lisa M McAndrew; Warren B Bilker; Virginia Elderkin-Thompson; Paul J Moberg Journal: Arch Clin Neuropsychol Date: 2011-12-21 Impact factor: 2.813
Authors: Rene Luis Olvera; Sheila C Caetano; Jeffrey A Stanley; Hua-Hsuan Chen; Mark Nicoletti; John P Hatch; Manoela Fonseca; Steven R Pliszka; Jair C Soares Journal: Psychiatry Res Date: 2010-11-30 Impact factor: 3.222
Authors: Kalynn M Schulz; Kristin M Andrud; Maria B Burke; Jennifer N Pearson; Alison D Kreisler; Karen E Stevens; Sherry Leonard; Catherine E Adams Journal: Dev Neurobiol Date: 2013-09-17 Impact factor: 3.964
Authors: Talaignair N Venkatraman; Ranga R Krishnan; David C Steffens; Allen W Song; Warren D Taylor Journal: Psychiatry Res Date: 2009-04-30 Impact factor: 3.222