Literature DB >> 11925283

Ondansetron in the treatment of cognitive decline in Alzheimer dementia.

Maurice Dysken1, Michael Kuskowski, Susan Love.   

Abstract

The authors performed a multicenter, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of ondansetron (20 microg/day and 100 microg/ day) in treating cognitive decline in 185 patients with Alzheimer disease. Although ondansetron was well tolerated without any serious drug-related side effects, the study failed to demonstrate any significant cognitive improvement.

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Year:  2002        PMID: 11925283

Source DB:  PubMed          Journal:  Am J Geriatr Psychiatry        ISSN: 1064-7481            Impact factor:   4.105


  3 in total

Review 1.  Alzheimer's disease and age-related memory decline (preclinical).

Authors:  Alvin V Terry; Patrick M Callahan; Brandon Hall; Scott J Webster
Journal:  Pharmacol Biochem Behav       Date:  2011-02-24       Impact factor: 3.533

2.  Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.

Authors:  Li Nan Zhang; Su Wen Su; Fang Guo; Hui Cai Guo; Xiao Lu Shi; Wen Ya Li; Xu Liu; Yong Li Wang
Journal:  BMC Neurosci       Date:  2012-01-19       Impact factor: 3.288

3.  Using predicate and provenance information from a knowledge graph for drug efficacy screening.

Authors:  Wytze J Vlietstra; Rein Vos; Anneke M Sijbers; Erik M van Mulligen; Jan A Kors
Journal:  J Biomed Semantics       Date:  2018-09-06
  3 in total

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