Literature DB >> 11925251

A general method for the preparation of 4- and 6-azaindoles.

Zhongxing Zhang1, Zhong Yang, Nicholas A Meanwell, John F Kadow, Tao Wang.   

Abstract

Nitropyridines reacted with an excess of vinyl Grignard reagent to produce 4- or 6-azaindoles. Improved yields were obtained when a halogen atom was present at the position alpha to the nitrogen atom in the pyridine ring.

Entities:  

Year:  2002        PMID： 11925251     DOI： 10.1021/jo0111614

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  C-H arylation of pyridines: high regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring.

Authors:  Pengfei Guo; Jung Min Joo; Souvik Rakshit; Dalibor Sames
Journal:  J Am Chem Soc       Date:  2011-09-22       Impact factor: 15.419

2.  Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution.

Authors:  Damian Antoniak; Michał Barbasiewicz
Journal:  Org Lett       Date:  2022-01-03       Impact factor: 6.005

Review 3.  In search of therapeutic candidates for HIV/AIDS: rational approaches, design strategies, structure-activity relationship and mechanistic insights.

Authors:  Dinesh Kumar; Pooja Sharma; Ramandeep Kaur; Maloba M M Lobe; Girish K Gupta; Fidele Ntie-Kang
Journal:  RSC Adv       Date:  2021-05-18       Impact factor: 4.036

Review 4.  Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir.

Authors:  Tao Wang; John F Kadow; Nicholas A Meanwell
Journal:  Med Chem Res       Date:  2021-09-28       Impact factor: 1.965
  4 in total

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