Literature DB >> 1192426

In vitro metabolism of benzo(a)pyrene by human liver microsomes and lymphocytes.

J K Selkirk, R G Croy, J P Whitlock, H V Gelboin.   

Abstract

The metabolism of benzo(a)pyrene by human liver microsomes and human lymphocytes has been analyzed by high-pressure liquid chromatography. Human liver forms seven known metabolites and at least five additional unidentified metabolites that migrate as distinct peaks. Lymphocytes incubated with benzo(a)pyrene for 30 min do not form dihydrodiols. Lymphocytes incubated for 24 hr with benzo(a)pyrene form all of the metabolites produced by liver including dihydrodiols as well as additional metabolites. The ratios of phenols formed by liver and lymphocytes are different, and preparations from humans form a different profile of metabolites than that formed by rat liver.

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Year:  1975        PMID： 1192426

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  7 in total

1.  The scientific imperative for use of human cells and organs in vitro: comparative toxicology and oncogenesis.

Authors:  T T Crocker
Journal:  In Vitro       Date:  1977-10

2.  High-throughput metabolic genotoxicity screening with a fluidic microwell chip and electrochemiluminescence.

Authors:  Dhanuka P Wasalathanthri; Spundana Malla; Itti Bist; Chi K Tang; Ronaldo C Faria; James F Rusling
Journal:  Lab Chip       Date:  2013-12-07       Impact factor: 6.799

3.  Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes.

Authors:  N Kaplowitz; C Spina; M Graham; J Kuhlenkamp
Journal:  Biochem J       Date:  1978-03-01       Impact factor: 3.857

4.  Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.

Authors:  Hao Jiang; Stacy L Gelhaus; Dipti Mangal; Ronald G Harvey; Ian A Blair; Trevor M Penning
Journal:  Chem Res Toxicol       Date:  2007-08-17       Impact factor: 3.739

5.  Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity.

Authors:  D Ross; D Siegel; D G Schattenberg; X M Sun; J L Moran
Journal:  Environ Health Perspect       Date:  1996-12       Impact factor: 9.031

Review 6.  Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice.

Authors:  J E Huff; J K Haseman; D M DeMarini; S Eustis; R R Maronpot; A C Peters; R L Persing; C E Chrisp; A C Jacobs
Journal:  Environ Health Perspect       Date:  1989-07       Impact factor: 9.031

7.  Cellular uptake and intracellular localization of benzo(a)pyrene by digital fluorescence imaging microscopy.

Authors:  A L Plant; D M Benson; L C Smith
Journal:  J Cell Biol       Date:  1985-04       Impact factor: 10.539
  7 in total

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