| Literature DB >> 11922805 |
Christophe Hardouin1, Eric Doris, Bernard Rousseau, Charles Mioskowski.
Abstract
[reaction: see text] The Cp(2)TiCl-mediated deoxygenation of leurosine (1) afforded anhydrovinblastine (4) in good yield. Furthermore, as the reaction proceeded via a carbon-centered radical intermediate, this transient was also trapped by a hydrogen-atom donor to afford selectively reduced alkaloid 10.Entities:
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Year: 2002 PMID： 11922805 DOI： 10.1021/ol025560c
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005