Literature DB >> 11922797

Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents.

Igor V Alabugin1, Mariappan Manoharan, Serguei V Kovalenko.   

Abstract

[reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.

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Year:  2002        PMID： 11922797     DOI： 10.1021/ol0255054

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Efficient and accurate characterization of the Bergman cyclization for several enediynes including an expanded substructure of esperamicin A1.

Authors:  Edward C Sherer; Karl N Kirschner; Frank C Pickard; Chantelle Rein; Steven Feldgus; George C Shields
Journal:  J Phys Chem B       Date:  2008-12-25       Impact factor: 2.991

2.  C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy.

Authors:  Wang-Yong Yang; Boris Breiner; Serguei V Kovalenko; Chi Ben; Mani Singh; Shauna N LeGrand; Qing-Xiang Amy Sang; Geoffrey F Strouse; John A Copland; Igor V Alabugin
Journal:  J Am Chem Soc       Date:  2009-08-19       Impact factor: 15.419

3.  Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells.

Authors:  Zchong-Zcho Wu; Ching-Ming Chien; Sheng-Huei Yang; Yi-Hsiung Lin; Xiu-Wei Hu; Yu-Jhang Lu; Ming-Jung Wu; Shinne-Ren Lin
Journal:  Mol Cell Biochem       Date:  2006-05-30       Impact factor: 3.396

4.  Two-photon photochemical generation of reactive enediyne.

Authors:  Andrei Poloukhtine; Vladimir V Popik
Journal:  J Org Chem       Date:  2006-09-15       Impact factor: 4.354

Review 5.  Computational studies on the regioselectivity of metal-catalyzed synthesis of 1,2,3 triazoles via click reaction: a review.

Authors:  Tayebeh Hosseinnejad; Bahareh Fattahi; Majid M Heravi
Journal:  J Mol Model       Date:  2015-09-18       Impact factor: 1.810

6.  Solving the puzzling competition of the thermal C(2)-C(6) vs Myers-Saito cyclization of enyne-carbodiimides.

Authors:  Anup Rana; Mehmet Emin Cinar; Debabrata Samanta; Michael Schmittel
Journal:  Beilstein J Org Chem       Date:  2016-01-11       Impact factor: 2.883

7.  Angle distortion model for predicting enediyne activation towards Bergman cyclization: an alternate to the distance theory.

Authors:  Prabuddha Bhattacharya; Soham Chakraborty; Ashwin Balaji; Amit Basak
Journal:  RSC Adv       Date:  2022-08-18       Impact factor: 4.036
  7 in total

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