Literature DB >> 11922786

Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligand.

H Charles Manning1, Timothy Goebel, John N Marx, Darryl J Bornhop.   

Abstract

[reaction: see text] Receptor-mediated imaging and therapy of diseased tissue is rapidly gaining favor in the medical community. The synthesis and facile aqueous/organic coupling of a peripheral-type benzodiazepine receptor ligand to a cyclen-based fluorophore is described herein. The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers.

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Year:  2002        PMID： 11922786     DOI： 10.1021/ol017155b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer.

Authors:  Shelby K Wyatt; H Charles Manning; Mingfeng Bai; Stephanie N Bailey; Pascal Gallant; Guobin Ma; Laura McIntosh; Darryl J Bornhop
Journal:  Mol Imaging Biol       Date:  2009-12-01       Impact factor: 3.488

2.  Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO.

Authors:  Michelle Sexton; Grace Woodruff; Eiron Cudaback; Faith R Kreitzer; Cong Xu; Yi Hsing Lin; Thomas Möller; Mingfeng Bai; H Charles Manning; Darryl Bornhop; Nephi Stella
Journal:  PLoS One       Date:  2009-12-18       Impact factor: 3.240

3.  Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO Ligand.

Authors:  Dewei Tang; Jason R Buck; Matthew R Hight; H Charles Manning
Journal:  Tetrahedron Lett       Date:  2010-09-01       Impact factor: 2.415

4.  A self-internalizing mitochondrial TSPO targeting imaging probe for fluorescence, MRI and EM.

Authors:  Lynn E Samuelson; Bernard M Anderson; Mingfeng Bai; Madeline J Dukes; Colette R Hunt; Jonathon D Casey; Zeqiu Han; Vassilios Papadopoulos; Darryl J Bornhop
Journal:  RSC Adv       Date:  2014-01-03       Impact factor: 3.361

5.  TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization.

Authors:  Lynn E Samuelson; Madeline J Dukes; Colette R Hunt; Jonathan D Casey; Darryl J Bornhop
Journal:  Bioconjug Chem       Date:  2009-11       Impact factor: 4.774

6.  Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.

Authors:  Heng Xu; Kwamena Baidoo; Andrew J Gunn; C Andrew Boswell; Diane E Milenic; Peter L Choyke; Martin W Brechbiel
Journal:  J Med Chem       Date:  2007-08-29       Impact factor: 7.446

7.  A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.

Authors:  C Andrew Boswell; Celeste A S Regino; Kwamena E Baidoo; Karen J Wong; Diane E Milenic; James A Kelley; Christopher C Lai; Martin W Brechbiel
Journal:  Bioorg Med Chem       Date:  2008-12-06       Impact factor: 3.641

8.  Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging.

Authors:  Heng Xu; Peter K Eck; Kwamena E Baidoo; Peter L Choyke; Martin W Brechbiel
Journal:  Bioorg Med Chem       Date:  2009-05-27       Impact factor: 3.641
  8 in total

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