Literature DB >> 11921746

[Tuberculosis in subjects under 15 years of age in the population of Warao in Venezuela].

Carlos Fernández de Larrea1, Cecil Fandiño, Diana López, Berenice del Nogal, Nilia Rodríguez, Jacinto Convit, Zaida Araujo, Jacobus H de Waard.   

Abstract

It is difficult to establish a definitive diagnosis of tuberculosis in rural areas where there is no access to a large hospital. The Warao people of the Delta Amacuro State in Venezuela, have a very high prevalence of adult TB, and we suspected that the Warao children would also have a high prevalence of the disease, almost entirely undiagnosed. We applied a simple methodology to select children suspicious for tuberculosis that is based on a rating system using clinical criteria, reactivity to tuberculin and intradomicilliary contacts. Of the 502 children under the age of 15 that were evaluated with this rating system, 27 were determined to be suspicious of TB and were further evaluated by a chest X-ray. Radiologic confirmation of TB was found in 16 (60%) of the 27 suspicious children. Of these 16 patients, 13 (81%) were PPD positive and 3 were PPD negative. Additionally, 7 of the 16 children with pathologic x-ray changes had one or more confirmatory findings: 3 were positive by culture or smear examination and 5 had a positive serologic B diagnostic test. In conclusion this methodology proved to be highly efficient in diagnosing childhood tuberculosis in this population, and should also be useful in other rural populations with a high prevalence of adult TB.

Entities:  

Mesh:

Year:  2002        PMID: 11921746

Source DB:  PubMed          Journal:  Invest Clin        ISSN: 0535-5133            Impact factor:   0.683


  7 in total

Review 1.  Burden of tuberculosis in indigenous peoples globally: a systematic review.

Authors:  D Tollefson; E Bloss; A Fanning; J T Redd; K Barker; E McCray
Journal:  Int J Tuberc Lung Dis       Date:  2013-07-02       Impact factor: 2.373

2.  Evidence of at least two introductions of HIV-1 in the Amerindian Warao population from Venezuela.

Authors:  Héctor R Rangel; Mailis Maes; Julian Villalba; Yoneira Sulbarán; Jacobus H de Waard; Gonzalo Bello; Flor H Pujol
Journal:  PLoS One       Date:  2012-07-12       Impact factor: 3.240

3.  Low child survival index in a multi-dimensionally poor Amerindian population in Venezuela.

Authors:  Julian A Villalba; Yushi Liu; Mauyuri K Alvarez; Luisana Calderon; Merari Canache; Gaudymar Cardenas; Berenice Del Nogal; Howard E Takiff; Jacobus H De Waard
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

4.  A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children.

Authors:  Lilly M Verhagen; Aldert Zomer; Mailis Maes; Julian A Villalba; Berenice Del Nogal; Marc Eleveld; Sacha Aft van Hijum; Jacobus H de Waard; Peter Wm Hermans
Journal:  BMC Genomics       Date:  2013-02-01       Impact factor: 3.969

5.  High malnutrition rate in Venezuelan Yanomami compared to Warao Amerindians and Creoles: significant associations with intestinal parasites and anemia.

Authors:  Lilly M Verhagen; Renzo N Incani; Carolina R Franco; Alejandra Ugarte; Yeneska Cadenas; Carmen I Sierra Ruiz; Peter W M Hermans; Denise Hoek; Maiza Campos Ponce; Jacobus H de Waard; Elena Pinelli
Journal:  PLoS One       Date:  2013-10-15       Impact factor: 3.240

6.  Agreement between QuantiFERON®-TB Gold In-Tube and the tuberculin skin test and predictors of positive test results in Warao Amerindian pediatric tuberculosis contacts.

Authors:  Lilly M Verhagen; Mailis Maes; Julian A Villalba; Adriana d'Alessandro; Lazaro Perez Rodriguez; Mercedes F España; Peter W M Hermans; Jacobus H de Waard
Journal:  BMC Infect Dis       Date:  2014-07-11       Impact factor: 3.090

7.  ESAT-6 and Ag85A Synthetic Peptides as Candidates for an Immunodiagnostic Test in Children with a Clinical Suspicion of Tuberculosis.

Authors:  Zaida Araujo; Carlos Fernández de Larrea; Diana López; Jaime Isern-Kebschull; Jacobus Henri de Waard; Isabel Hagel; Milena Camargo; Magnolia Vanegas; Manuel A Patarroyo
Journal:  Dis Markers       Date:  2021-07-06       Impact factor: 3.434

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.