Literature DB >> 11921185

Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Elizabeth G Snyderwine1.   

Abstract

The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of these compounds, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the major one present in the human diet. This report reviews the studies on rat mammary gland carcinogenesis by HCAs; discusses what is currently known regarding mechanisms of mammary gland carcinogenesis of PhIP, especially the significance of metabolic processing; and further highlights the evidence for the possible role of PhIP in human breast cancer.

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Year:  2002        PMID： 11921185     DOI： 10.1002/em.10053

Source DB:  PubMed          Journal:  Environ Mol Mutagen        ISSN： 0893-6692            Impact factor:   3.216


  7 in total

Review 1.  Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood.

Authors:  Suzanne E Fenton; Casey Reed; Retha R Newbold
Journal:  Annu Rev Pharmacol Toxicol       Date:  2011-10-19       Impact factor: 13.820

2.  Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.

Authors:  Kana Wu; Rashmi Sinha; Michelle D Holmes; Edward Giovannucci; Walter Willett; Eunyoung Cho
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-05       Impact factor: 4.254

Review 3.  Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.

Authors:  Robert J Turesky; Loic Le Marchand
Journal:  Chem Res Toxicol       Date:  2011-06-20       Impact factor: 3.739

4.  Polymorphisms in xenobiotic metabolizing genes, intakes of heterocyclic amines and red meat, and postmenopausal breast cancer.

Authors:  Hae-Jeung Lee; Kana Wu; David G Cox; David Hunter; Susan E Hankinson; Walter C Willett; Rashmi Sinha; Eunyoung Cho
Journal:  Nutr Cancer       Date:  2013-10-07       Impact factor: 2.900

Review 5.  Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment.

Authors:  Connie Cheung; Frank J Gonzalez
Journal:  J Pharmacol Exp Ther       Date:  2008-08-05       Impact factor: 4.030

6.  Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.

Authors:  Kristin J Baldauf; Raúl A Salazar-González; Mark A Doll; William M Pierce; J Christopher States; David W Hein
Journal:  Environ Mol Mutagen       Date:  2019-09-30       Impact factor: 3.216

7.  Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression.

Authors:  Liang Shan; Minshu Yu; Herman A J Schut; Elizabeth G Snyderwine
Journal:  Am J Pathol       Date:  2004-07       Impact factor: 4.307
  7 in total

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