Literature DB >> 11920915

Toxicology update: the cardiotoxicity of the oxidative stress metabolites of catecholamines (aminochromes).

G S Behonick1, M J Novak, E W Nealley, S I Baskin.   

Abstract

This toxicology update reviews the oxidative stress metabolites of catecholamines, postulated to be the biochemical initiators of cardiotoxicity. A brief overview of catecholamine metabolism is provided with several noteworthy historical observations relating to the autoxidation and rearrangement of epinephrine. The basic chemical and physical properties of adrenochrome and adrenolutin are discussed. The autoxidative, enzymatic and cellular basis for the transformation of catecholamines to oxidative metabolites is reviewed. Mechanisms seeking to account for the observed cardiotoxic changes in isolated heart perfusion studies and in vivo models are described. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11920915     DOI： 10.1002/jat.793

Source DB:  PubMed          Journal:  J Appl Toxicol        ISSN： 0260-437X            Impact factor:   3.446


  14 in total

1.  Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.

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3.  Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.

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4.  Exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in Akt activity and matrix metalloproteinase expression.

Authors:  Christopher R Daniels; Cerrone R Foster; Sana Yakoob; Suman Dalal; William L Joyner; Mahipal Singh; Krishna Singh
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Review 5.  Red Blood Cell Dysfunction in Critical Illness.

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Review 6.  Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?

Authors:  Jenn Rachelle U Santos; Alessandra Brofferio; Bruna Viana; Karel Pacak
Journal:  Horm Metab Res       Date:  2018-09-18       Impact factor: 2.936

7.  An unusual presentation of pheochromocytoma.

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Journal:  NDT Plus       Date:  2011-05-06

8.  Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats.

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Journal:  J Cell Mol Med       Date:  2007 Jan-Feb       Impact factor: 5.310

Review 9.  Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress.

Authors:  Manuela Graziani; Letizia Antonilli; Anna Rita Togna; Maria Caterina Grassi; Aldo Badiani; Luciano Saso
Journal:  Oxid Med Cell Longev       Date:  2015-12-28       Impact factor: 6.543

10.  Pheochromocytoma mimicking both acute coronary syndrome and sepsis: a case report.

Authors:  Ting-Wei Lee; Ke-Hsun Lin; Chun-Jen Chang; Wei-Han Lew; Ting-I Lee
Journal:  Med Princ Pract       Date:  2012-10-27       Impact factor: 1.927
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