Literature DB >> 11920821

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy.

Julie Bestman-Smith1, Guy Boivin.   

Abstract

Sequential herpes simplex virus (HSV) isolates from AIDS patients receiving foscarnet therapy were evaluated for susceptibility to adefovir. Foscarnet-resistant isolates with DNA polymerase mutations in regions II, VI, and between I and VII were also associated with an important decrease in susceptibility to adefovir (mean IC50 increase: 4.6-fold compared to pre-foscarnet or wild-type isolates) suggesting that adefovir-resistant HSV could be selected in vivo by foscarnet therapy. Copyright 2002 Wiley-Liss, Inc.

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Year:  2002        PMID： 11920821     DOI： 10.1002/jmv.2195

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  7 in total

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Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

5.  Antiviral Drugs Against Herpesviruses.

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6.  A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity.

Authors:  Ying T Hwang; Harmon J Zuccola; Qiaosheng Lu; Charles B C Hwang
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

7.  Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.

Authors:  Robert P Hayes; Mee Ra Heo; Mark Mason; John Reid; Christine Burlein; Kira A Armacost; David M Tellers; Izzat Raheem; Anthony W Shaw; Edward Murray; Philip M McKenna; Pravien Abeywickrema; Sujata Sharma; Stephen M Soisson; Daniel Klein
Journal:  Nat Commun       Date:  2021-05-24       Impact factor: 14.919
  7 in total

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