BACKGROUND: Although the APC/beta-catenin pathway is known to play a crucial role in sporadic colorectal carcinogenesis, its influence on ulcerative colitis (UC)-related neoplastic progression is unknown. To elucidate the role of the APC-/beta-catenin pathway in UC-related carcinogenesis, the authors identified APC and beta-catenin mutations in a set of UC-related and sporadic colorectal carcinomas. METHODS: The mutational cluster region of APC (codon 1267 to 1529) and exon 3 of the beta-catenin were directly sequenced. RESULTS: Only 1 of 30 UC-related tumors (3%) showed an APC mutation whereas 11 of the 42 sporadic carcinomas (26%) had mutations within the mutational cluster region. Within the sporadic carcinoma group, only 8% of the right-sided carcinomas showed APC mutations whereas 50% of the left-sided carcinomas had mutations within the mutational cluster region. None of the tumors in either group showed a beta-catenin mutation. CONCLUSIONS: Mutations of the APC and beta-catenin are rare in UC-related tumors. These genes may be altered because of mutations outside the regions studied, or by epigenetic silencing. Alternatively, other proteins involved in the APC/beta-catenin signaling cascade may be altered, or this pathway may be involved infrequently in UC-related carcinogenesis. The significant difference in frequency of APC mutations between right- and left-sided sporadic tumors suggests different molecular pathways in these two tumor sites. Copyright 2002 American Cancer Society.
BACKGROUND: Although the APC/beta-catenin pathway is known to play a crucial role in sporadic colorectal carcinogenesis, its influence on ulcerative colitis (UC)-related neoplastic progression is unknown. To elucidate the role of the APC-/beta-catenin pathway in UC-related carcinogenesis, the authors identified APC and beta-catenin mutations in a set of UC-related and sporadic colorectal carcinomas. METHODS: The mutational cluster region of APC (codon 1267 to 1529) and exon 3 of the beta-catenin were directly sequenced. RESULTS: Only 1 of 30 UC-related tumors (3%) showed an APC mutation whereas 11 of the 42 sporadic carcinomas (26%) had mutations within the mutational cluster region. Within the sporadic carcinoma group, only 8% of the right-sided carcinomas showed APC mutations whereas 50% of the left-sided carcinomas had mutations within the mutational cluster region. None of the tumors in either group showed a beta-catenin mutation. CONCLUSIONS: Mutations of the APC and beta-catenin are rare in UC-related tumors. These genes may be altered because of mutations outside the regions studied, or by epigenetic silencing. Alternatively, other proteins involved in the APC/beta-catenin signaling cascade may be altered, or this pathway may be involved infrequently in UC-related carcinogenesis. The significant difference in frequency of APC mutations between right- and left-sided sporadic tumors suggests different molecular pathways in these two tumor sites. Copyright 2002 American Cancer Society.
Authors: Peter Balaz; Jens Plaschke; Stefan Krüger; Heike Görgens; Hans K Schackert Journal: Int J Colorectal Dis Date: 2010-06-08 Impact factor: 2.571
Authors: Li-Shu Wang; Chieh-Ti Kuo; Tim H-M Huang; Martha Yearsley; Kiyoko Oshima; Gary D Stoner; Jianhua Yu; John F Lechner; Yi-Wen Huang Journal: Cancer Prev Res (Phila) Date: 2013-10-15
Authors: P Chandrasinghe; B Cereser; M Moorghen; I Al Bakir; N Tabassum; A Hart; J Stebbing; J Warusavitarne Journal: Oncogene Date: 2017-09-04 Impact factor: 9.867
Authors: S Fujii; T Fujimori; H Kawamata; J Takeda; K Kitajima; F Omotehara; T Kaihara; T Kusaka; K Ichikawa; Y Ohkura; Y Ono; J Imura; S Yamaoka; C Sakamoto; Y Ueda; T Chiba Journal: Gut Date: 2004-05 Impact factor: 23.059
Authors: Anitha K Shenoy; Robert C Fisher; Elizabeth A Butterworth; Liya Pi; Lung-Ji Chang; Henry D Appelman; Myron Chang; Edward W Scott; Emina H Huang Journal: Cancer Res Date: 2012-08-17 Impact factor: 12.701