Literature DB >> 11919686

Congenic mapping of a blood pressure QTL on chromosome 16 of Dahl rats.

Myriam Moujahidine1, Julie Dutil, Pavel Hamet, Alan Y Deng.   

Abstract

A Chromosome (Chr) 16 segment of the Dahl salt-sensitive (S) rat was shown by linkage to contain a blood pressure (BP) quantitative trait locus (QTL). To verify and further narrow down the region harboring the QTL, we made two congenic strains by replacing two segments of the S rats with the homologous segments of the Lewis (LEW) rats. The construction of these congenic strains was facilitated by a genome-wide marker screening. The two congenic strains contained a segment in common, and BPs of both were significantly lower than that of the S strain. Consequently, a BP QTL could be localized to the overlapping region of about 49.4 centiRay (cR) including the telomere on a radiation hybrid map. Heart weights, left and right ventricular weights, kidney weights, and aortic weights over length were all significantly decreased in the congenic strains compared with the S strain. Thus, there appeared to exist an association between the effects of the QTL on BP and on cardiac, renal, and vascular hypertrophy.

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Mesh：

Year:  2002        PMID： 11919686     DOI： 10.1007/BF02684020

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  15 in total

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2.  Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats.

Authors:  M R Garrett; H Dene; R Walder; Q Y Zhang; G T Cicila; S Assadnia; A Y Deng; J P Rapp
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Authors:  A Y Deng; W H Smith-Mensah; B Hoebee; M Garrett; J P Rapp
Journal:  Mamm Genome       Date:  1998-01       Impact factor: 2.957

Review 4.  Reflections on telomeres, growth, aging, and essential hypertension.

Authors:  A Aviv; H Aviv
Journal:  Hypertension       Date:  1997-05       Impact factor: 10.190

5.  Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2.

Authors:  B Jeffs; C D Negrin; D Graham; J S Clark; N H Anderson; D Gauguier; A F Dominiczak
Journal:  Hypertension       Date:  2000-01       Impact factor: 10.190

6.  Workshop: excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells?

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7.  A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.

Authors:  M T Bihoreau; L Sebag-Montefiore; R F Godfrey; R H Wallis; J H Brown; P A Danoy; S C Collins; M Rouard; P J Kaisaki; M Lathrop; D Gauguier
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8.  Cosegregation analysis in genetic crosses suggests a protective role for atrial natriuretic factor against ventricular hypertrophy.

Authors:  S Masciotra; S Picard; C F Deschepper
Journal:  Circ Res       Date:  1999-06-25       Impact factor: 17.367

9.  Further chromosomal mapping of a blood pressure QTL in Dahl rats on chromosome 2 using congenic strains.

Authors:  J Dutil; A Y Deng
Journal:  Physiol Genomics       Date:  2001-06-06       Impact factor: 3.107

10.  Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

Authors:  A Y Deng; H Dene; M Pravenec; J P Rapp
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808
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  6 in total

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Journal:  Physiol Genomics       Date:  2010-09-14       Impact factor: 3.107

2.  Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat.

Authors:  A J Kriegel; A S Greene
Journal:  Physiol Genomics       Date:  2008-10-21       Impact factor: 3.107

3.  High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.

Authors:  Anne E Kwitek; Jo Gullings-Handley; Jiaming Yu; Danilo C Carlos; Kimberly Orlebeke; Jeff Nie; Jeffrey Eckert; Angela Lemke; Jaime Wendt Andrae; Susan Bromberg; Dean Pasko; Dan Chen; Todd E Scheetz; Thomas L Casavant; M Bento Soares; Val C Sheffield; Peter J Tonellato; Howard J Jacob
Journal:  Genome Res       Date:  2004-04       Impact factor: 9.043

4.  Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.

Authors:  David L Mattson; Melinda R Dwinell; Andrew S Greene; Anne E Kwitek; Richard J Roman; Howard J Jacob; Allen W Cowley
Journal:  Am J Physiol Renal Physiol       Date:  2008-07-23

Review 5.  Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.

Authors:  Sandosh Padmanabhan; Bina Joe
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6.  Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats.

Authors:  Chenda Duong; Sophie Charron; Chunjie Xiao; Pavel Hamet; Annie Ménard; Julie Roy; Alan Y Deng
Journal:  Mamm Genome       Date:  2006-12-01       Impact factor: 3.224
  6 in total

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