Literature DB >> 11918061

CJ-21,058, a new SecA inhibitor isolated from a fungus.

Yutaka Sugie1, Sae Inagaki, Yoshinao Kato, Hiroyuki Nishida, Chang-Hong Pang, Toshiyuki Saito, Shinichi Sakemi, Fadia Dib-Hajj, John P Mueller, Joyce Sutcliffe, Yasuhiro Kojima.   

Abstract

A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane.

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Year:  2002        PMID： 11918061     DOI： 10.7164/antibiotics.55.25

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  15 in total

Review 1.  Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?

Authors:  Meghan E Feltcher; Jonathan Tabb Sullivan; Miriam Braunstein
Journal:  Future Microbiol       Date:  2010-10       Impact factor: 3.165

Review 2.  SecA inhibitors as potential antimicrobial agents: differential actions on SecA-only and SecA-SecYEG protein-conducting channels.

Authors:  Jinshan Jin; Ying-Hsin Hsieh; Arpana S Chaudhary; Jianmei Cui; John E Houghton; Sen-Fang Sui; Binghe Wang; Phang C Tai
Journal:  FEMS Microbiol Lett       Date:  2018-08-01       Impact factor: 2.742

Review 3.  SecA: a potential antimicrobial target.

Authors:  Arpana S Chaudhary; Weixuan Chen; Jinshan Jin; Phang C Tai; Binghe Wang
Journal:  Future Med Chem       Date:  2015       Impact factor: 3.808

4.  Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

Authors:  Evelien De Waelheyns; Kenneth Segers; Marios Frantzeskos Sardis; Jozef Anné; Gerry A F Nicolaes; Anastassios Economou
Journal:  J Antibiot (Tokyo)       Date:  2015-05-20       Impact factor: 2.649

5.  Nature-inspired total synthesis of (-)-fusarisetin A.

Authors:  Jing Xu; Eduardo J E Caro-Diaz; Lynnie Trzoss; Emmanuel A Theodorakis
Journal:  J Am Chem Soc       Date:  2012-03-08       Impact factor: 15.419

6.  Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation.

Authors:  Ying-Ju Huang; Hongyun Wang; Fen-Biao Gao; Minyong Li; Hsiuchin Yang; Binghe Wang; Phang C Tai
Journal:  ChemMedChem       Date:  2012-02-22       Impact factor: 3.466

7.  Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.

Authors:  Jinshan Jin; Ying-Hsin Hsieh; Jianmei Cui; Krishna Damera; Chaofeng Dai; Arpana S Chaudhary; Hao Zhang; Hsiuchin Yang; Nannan Cao; Chun Jiang; Martti Vaara; Binghe Wang; Phang C Tai
Journal:  ChemMedChem       Date:  2016-10-18       Impact factor: 3.466

8.  The first low microM SecA inhibitors.

Authors:  Weixuan Chen; Ying-ju Huang; Sushma Reddy Gundala; Hsiuchin Yang; Minyong Li; Phang C Tai; Binghe Wang
Journal:  Bioorg Med Chem       Date:  2010-01-06       Impact factor: 3.641

9.  Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities.

Authors:  Bhargavi Patham; Josh Duffy; Ariel Lane; Richard C Davis; Peter Wipf; Sheara W Fewell; Jeffrey L Brodsky; Kojo Mensa-Wilmot
Journal:  Biochem J       Date:  2009-04-15       Impact factor: 3.857

10.  Optimization of Thiazolidone Scaffolds Using Pocket Modeling for Development of Potential Secretory System Inhibitors of Mycobacterium tuberculosis.

Authors:  Shivratna V Khare; Sujata P Choudhari; Siddharth P Phalle; Santosh S Kumbhar; Prafulla B Choudhari; Sambhaji R Masal; Aakash K Patil; Rakesh P Dhavale; Durgacharan A Bhagwat; Atul M Kadam
Journal:  Turk J Pharm Sci       Date:  2019-03-27
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