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Literature DB >> 11916532

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.

M A Vos¹, J M van Opstal, J D Leunissen, S C Verduyn.

Abstract

When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential before approving it for clinical practice. In this review, identified predisposing factors have been related to specific electrophysiological parameters, allowing quantification of their contribution to Torsade de Pointes arrhythmias. In addition, arrhythmogenic mechanisms involved in the initiation and perpetuation of drug-induced Torsade de Pointes are discussed.

Entities: Disease

Mesh：

Substances：
Anti-Arrhythmia Agents

Year: 2001 PMID： 11916532 DOI： 10.1016/s0163-7258(01)00162-0

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

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Cited

12 in total

Review 1. Drugs, QT interval prolongation and ICH E14: the need to get it right.

Authors: Rashmi R Shah
Journal: Drug Saf Date: 2005 Impact factor: 5.606

2. T-wave morphology parameters based on principal component analysis reproducibility and dependence on T-offset position.

Authors: Fabrice Extramiana; Abdeddayem Haggui; Pierre Maison-Blanche; Rémi Dubois; Seiji Takatsuki; Philippe Beaufils; Antoine Leenhardt
Journal: Ann Noninvasive Electrocardiol Date: 2007-10 Impact factor: 1.468

3. ECG evaluation of ventricular properties: the importance of cardiac cycle length.

Authors: Fabrice Extramiana; Antoine Leenhardt; Pierre Maison-Blanche
Journal: Ann Noninvasive Electrocardiol Date: 2009-01 Impact factor: 1.468

4. The time course of new T-wave ECG descriptors following single- and double-dose administration of sotalol in healthy subjects.

Authors: Fabrice Extramiana; Rémi Dubois; Martino Vaglio; Pierre Roussel; Gerard Dreyfus; Fabio Badilini; Antoine Leenhardt; Pierre Maison-Blanche
Journal: Ann Noninvasive Electrocardiol Date: 2010-01 Impact factor: 1.468

Review 10. Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.

Authors: M A Vos
Journal: Br J Pharmacol Date: 2008-07-07 Impact factor: 8.739

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.

Review 1. Drugs, QT interval prolongation and ICH E14: the need to get it right.

2. T-wave morphology parameters based on principal component analysis reproducibility and dependence on T-offset position.

3. ECG evaluation of ventricular properties: the importance of cardiac cycle length.

4. The time course of new T-wave ECG descriptors following single- and double-dose administration of sotalol in healthy subjects.

Review 5. Evolution of strategies to improve preclinical cardiac safety testing.

6. Limited role of Ca²⁺-activated Cl^- current in early afterdepolarisations.

7. Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

8. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations.

Review 9. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.

Review 10. Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.

Review 1. Drugs, QT interval prolongation and ICH E14: the need to get it right.

2. T-wave morphology parameters based on principal component analysis reproducibility and dependence on T-offset position.

3. ECG evaluation of ventricular properties: the importance of cardiac cycle length.

4. The time course of new T-wave ECG descriptors following single- and double-dose administration of sotalol in healthy subjects.

Review 5. Evolution of strategies to improve preclinical cardiac safety testing.

6. Limited role of Ca2+-activated Cl- current in early afterdepolarisations.

7. Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

8. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations.

Review 9. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.

Review 10. Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.

6. Limited role of Ca²⁺-activated Cl^- current in early afterdepolarisations.