| Literature DB >> 11916518 |
Vijaya Vegesna1, Seisho Takeuchi, Wolf-K Hofmann, Takayuki Ikezoe, Sigal Tavor, Utz Krug, Anthony C Fermin, Anthony Heaney, Carl W Miller, H Phillip Koeffler.
Abstract
Mutations of transcription factors are associated with the pathogenesis of cancer. Genomic DNA from 381 cancers and cell lines representing leukemias, lymphomas and a variety of solid tumors were examined for mutations of genes coding for the C/EBP-beta, C/EBP-alpha, PU.1, and AML1 transcription factors using single strand conformation polymorphism (SSCP) and direct DNA sequencing. Mutation of C/EBP-beta (a chronic myelogenous leukemia cell line, Kcl22) and C/EBP-delta (a Burkitt's lymphoma cell line, Raji) were found. Interestingly, the sample with a C/EBP-beta alterations had two missense (P236L and G252A) and two silent mutations in a highly conserved region of the gene. The C/EBP-delta alteration in Raji was a missense mutation (A177G). These findings suggest that mutations of the C/EBP-beta, C/EBP-delta, PU.1, and AML1 rarely contribute to the development of hematopoietic or solid cancers.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11916518 DOI： 10.1016/s0145-2126(01)00150-3
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156