| Literature DB >> 11916069 |
Tammy L Moser1, M Sharon Stack, Miriam L Wahl, Salvatore V Pizzo.
Abstract
What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.Entities:
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Year: 2002 PMID： 11916069
Source DB: PubMed Journal: Thromb Haemost ISSN： 0340-6245 Impact factor: 5.249