| Literature DB >> 11915005 |
Susan Clarke1, Fiona Mulcahy, Colm Bergin, Helen Reynolds, Nicola Boyle, Michael Barry, David J Back.
Abstract
A study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.Entities:
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Year: 2002 PMID: 11915005 DOI: 10.1086/339541
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079