Literature DB >> 11915005

Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.

Susan Clarke1, Fiona Mulcahy, Colm Bergin, Helen Reynolds, Nicola Boyle, Michael Barry, David J Back.   

Abstract

A study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.

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Year:  2002        PMID: 11915005     DOI: 10.1086/339541

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  12 in total

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Review 2.  A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products.

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Journal:  J Med Toxicol       Date:  2015-09

3.  Nevirapine significantly reduces the levels of racemic methadone and (R)-methadone in human immunodeficiency virus-infected patients.

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Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

4.  Strategies to improve access to and utilization of health care services and adherence to antiretroviral therapy among HIV-infected drug users.

Authors:  Chinazo O Cunningham; Nancy L Sohler; Nina A Cooperman; Karina M Berg; Alain H Litwin; Julia H Arnsten
Journal:  Subst Use Misuse       Date:  2011       Impact factor: 2.164

5.  Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.

Authors:  E D Kharasch; P S Bedynek; S Park; D Whittington; A Walker; C Hoffer
Journal:  Clin Pharmacol Ther       Date:  2008-10       Impact factor: 6.875

6.  Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.

Authors:  Evan D Kharasch; Christine Hoffer; Dale Whittington; Alysa Walker; Pamela Sheffels Bedynek
Journal:  Anesthesiology       Date:  2009-03       Impact factor: 7.892

7.  Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir.

Authors:  Evan D Kharasch; Kristi Stubbert
Journal:  Drug Metab Dispos       Date:  2013-09-25       Impact factor: 3.922

Review 8.  Practical considerations for the clinical use of buprenorphine.

Authors:  Hendree E Jones
Journal:  Sci Pract Perspect       Date:  2004-08

Review 9.  Lopinavir/ritonavir: a review of its use in the management of HIV infection.

Authors:  Risto S Cvetkovic; Karen L Goa
Journal:  Drugs       Date:  2003       Impact factor: 9.546

Review 10.  Polypharmacy in the HIV-infected older adult population.

Authors:  Lauren J Gleason; Amneris E Luque; Krupa Shah
Journal:  Clin Interv Aging       Date:  2013-06-21       Impact factor: 4.458

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