Literature DB >> 11914956

Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations.

Mei Lu1, Lucia Battinelli, Claudia Daniele, Cristiana Melchioni, Giuseppe Salvatore, Gabriela Mazzanti.   

Abstract

The muscle relaxing activity of the essential oil of Hyssopus officinalis L. (Lamiaceae) and some of its main components (isopinocamphone, limonene and beta-pinene) was studied on isolated preparations of guinea-pig and rabbit intestine. The essential oil and isopinocamphone inhibited the acetylcholine- and BaCl2-induced contractions in guinea-pig ileum in a concentration-dependent manner (IC50 42.4 microg/ml and 61.9 microg/ml to acetylcholine; 48.3 microg/ml and 70.4 microg/ml to BaCl2) whereas limonene or beta-pinene left tissue contraction unchanged. In guinea-pig ileum H. officinalis essential oil also blocked the contractions induced by CaCl2. In isolated rabbit jejunum the essential oil reduced the amplitude of spontaneous movements and decreased the basal tone; neither haemoglobin, methylene blue, N(omega)-nitro-L-arginine methyl ester (L-NAME) or propranolol blocked the myorelaxant effect.

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Year:  2002        PMID： 11914956     DOI： 10.1055/s-2002-23139

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


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