Literature DB >> 1191487

Biliary excretion of diazepam in man.

P W Eustace, D M Hailey, A G Cox, E S Baird.   

Abstract

In a study of diazepam metabolism, diazepam 10 mg was administered i.m. to four patients who had biliary T-tube drainage. Blood and bile diazepam metabolite concentrations were measured for 12 hr. The expected fluctuations in blood diazepam concentrations were seen, and conjugated diazepam metabolites were present in human bile. Bile diazepam concentrations were insufficient to account for an enterohepatic circulation.

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Year:  1975        PMID: 1191487     DOI: 10.1093/bja/47.9.983

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN: 0007-0912            Impact factor:   9.166


  4 in total

1.  Pharmacokinetics of intravenous anaesthetics: implications for clinical use.

Authors:  M M Ghoneim; K Korttila
Journal:  Clin Pharmacokinet       Date:  1977 Sep-Oct       Impact factor: 6.447

2.  Pharmacokinetics of prazepam in man.

Authors:  M T Smith; L E Evans; M J Eadie; J H Tyrer
Journal:  Eur J Clin Pharmacol       Date:  1979-09       Impact factor: 2.953

3.  Diurnal variations in plasma diazepam concentrations associated with reciprocal changes in free fraction.

Authors:  C A Naranjo; E M Sellers; H G Giles; J G Abel
Journal:  Br J Clin Pharmacol       Date:  1980-03       Impact factor: 4.335

4.  Biliary excretion of diazepam and its metabolites in man after repeated oral doses.

Authors:  R Sellman; M Hurme; J Kanto
Journal:  Eur J Clin Pharmacol       Date:  1977-11-14       Impact factor: 2.953

  4 in total

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