Literature DB >> 1191485

Effect of pentobarbitone on hypoxic ventilatory drive in man: Preliminary study.

C A Hirshman, R E McCullough, P J Cohen, J V Weil.   

Abstract

The effect of an intramuscular injection of pentobarbitone 2 mg/kg on the hypoxic ventilatory drive was measured in 10 volunteers. Five subjects showed significant depression of the ventilatory response to hypoxia 30 min after administration. This depression persisted for 90 min. The other five subjects showed no change from control responses. The two groups appeared to differ in their levels of physical fitness as measured by differences in resting heart rate and maximal oxygen uptake.

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Year:  1975        PMID: 1191485     DOI: 10.1093/bja/47.9.963

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN: 0007-0912            Impact factor:   9.166


  4 in total

Review 1.  The role of research in pain control for dentistry.

Authors:  G D Allen
Journal:  Anesth Prog       Date:  1987 Nov-Dec

Review 2.  Control of breathing: effects of analgesic, anaesthetic and neuromuscular blocking drugs.

Authors:  R L Knill
Journal:  Can J Anaesth       Date:  1988-05       Impact factor: 5.063

3.  Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man.

Authors:  R L Knill; S Bright; P Manninen
Journal:  Can Anaesth Soc J       Date:  1978-09

4.  The ventilatory response to hypoxia in the anesthetized rat.

Authors:  F Hayashi; A Yoshida; Y Fukuda; Y Honda
Journal:  Pflugers Arch       Date:  1983-02       Impact factor: 3.657

  4 in total

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