Literature DB >> 11914777

Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.

Daan Noort1, Albert G Hulst, Rob Jansen.   

Abstract

Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adducts is presented, based on liquid chromatography-tandem mass spectrometry analysis of the adducted tripeptide Cys*-Pro-Phe after digestion of the protein with Pronase.

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Year:  2002        PMID： 11914777     DOI： 10.1007/s00204-001-0318-2

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

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7.  A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts.

Authors:  Brooke G Pantazides; Jennifer Quiñones-González; Danisha M Rivera Nazario; Brian S Crow; Jonas W Perez; Thomas A Blake; Rudolph C Johnson
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Authors:  Jose R Cortes; Christina C Patrone; Stuart Aidan Quinn; Yuhan Gu; Marta Sanchez-Martin; Adam Mackey; Anisha J Cooke; Bobby B Shih; Anouchka P Laurent; Megan H Trager; Adolfo A Ferrando; Larisa J Geskin; Teresa Palomero
Journal:  J Invest Dermatol       Date:  2021-06-03       Impact factor: 7.590
  10 in total

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