R A Sweet1, V L Nimgaonkar, B Devlin, O L Lopez, S T DeKosky. 1. Division of Geriatrics and Neuropsychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. SweetRA@MSX.UPMC.EDU
Abstract
BACKGROUND: Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. OBJECTIVE: To determine if AD+P aggregates within families. METHODS: Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families. RESULTS: AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16. CONCLUSION: AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.
BACKGROUND:Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. OBJECTIVE: To determine if AD+P aggregates within families. METHODS: Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families. RESULTS:AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16. CONCLUSION:AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.
Authors: Mary Ann A DeMichele-Sweet; Lambertus Klei; Bernie Devlin; Robert E Ferrell; Elise A Weamer; James E Emanuel; Oscar L Lopez; Robert A Sweet Journal: Neurobiol Aging Date: 2010-11-18 Impact factor: 4.673
Authors: Angela Nervi; Christiane Reitz; Ming-Xin Tang; Vincent Santana; Angel Piriz; Dolly Reyes; Rafael Lantigua; Martin Medrano; Ivonne Z Jiménez-Velázquez; Joseph H Lee; Richard Mayeux Journal: Arch Neurol Date: 2011-01
Authors: Patrick S Murray; Caitlin M Kirkwood; Megan C Gray; Milos D Ikonomovic; William R Paljug; Eric E Abrahamson; Ruth A Henteleff; Ronald L Hamilton; Julia K Kofler; William E Klunk; Oscar L Lopez; Peter Penzes; Robert A Sweet Journal: Neurobiol Aging Date: 2012-03-17 Impact factor: 4.673
Authors: A L Pritchard; J Harris; C W Pritchard; J Coates; S Haque; R Holder; P Bentham; C L Lendon Journal: J Neurol Neurosurg Psychiatry Date: 2006-09-15 Impact factor: 10.154
Authors: Elise A Weamer; James E Emanuel; Daniel Varon; Sachiko Miyahara; Patricia A Wilkosz; Oscar L Lopez; Steven T Dekosky; Robert A Sweet Journal: Int Psychogeriatr Date: 2008-09-25 Impact factor: 3.878