Literature DB >> 11913762

The non-steroidal anti-inflammatory drug niflumic acid inhibits Candida albicans growth.

Andrew Baker1, Frederick D Northrop, Hendrik Miedema, Gary R Devine, Julia M Davies.   

Abstract

The non-steroidal anti-inflammatory drug niflumic acid was found to inhibit growth of the yeast form of Candida albicans. Niflumic acid inhibited respiratory oxygen uptake and it is hypothesised that this was achieved by cytosolic acidification and block of glycolysis. Inhibitory concentrations are compatible with current practice of topical application.

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Year:  2002        PMID： 11913762     DOI： 10.1023/a:1015248027394

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  16 in total

1.  Antifungal susceptibility testing of Candida spp. by relative growth measurement at single concentrations of antifungal agents.

Authors:  F C Odds
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

2.  Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs.

Authors:  R I Allen; K J Box; J E Comer; C Peake; K Y Tam
Journal:  J Pharm Biomed Anal       Date:  1998-08       Impact factor: 3.935

3.  Influence of Na+ and anions on the dimorphic transition of Candida albicans.

Authors:  Frederick D Northrop; Srdjan Ljubojevic; Julia M Davies
Journal:  Microbiology (Reading)       Date:  1997-12       Impact factor: 2.777

4.  Chloride channel blockers decrease intracellular pH in cultured renal epithelial LLC-PK1 cells.

Authors:  C D Brown; A J Dudley
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

5.  Effect of benzoate on the metabolism of fructose 2,6-bisphosphate in yeast.

Authors:  J François; E Van Schaftingen; H G Hers
Journal:  Eur J Biochem       Date:  1986-01-02

6.  Cytoplasmic alkalinization during germ tube formation in Candida albicans.

Authors:  E Stewart; N A Gow; D V Bowen
Journal:  J Gen Microbiol       Date:  1988-05

7.  Quantitative determination of niflumic acid and its beta-morpholinoethyl ester in human plasma by gas-liquid chromatography.

Authors:  G Houin; F Bree; J P Tillement
Journal:  J Chromatogr       Date:  1981-05-08

8.  Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system.

Authors:  J Barnett; J Chow; D Ives; M Chiou; R Mackenzie; E Osen; B Nguyen; S Tsing; C Bach; J Freire
Journal:  Biochim Biophys Acta       Date:  1994-11-16

9.  Determination of protonation macro- and microconstants and octanol/water partition coefficient of the antiinflammatory drug niflumic acid.

Authors:  K Takács-Novák; A Avdeef; K J Box; B Podányi; G Szász
Journal:  J Pharm Biomed Anal       Date:  1994-11       Impact factor: 3.935

10.  Intracellular pH of Candida albicans blastospores as measured by laser microspectrofluorimetry and 31P-NMR.

Authors:  F Rabaste; M Sancelme; A M Delort; J Blais; J Bolard
Journal:  Biochim Biophys Acta       Date:  1995-07-20
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