Literature DB >> 1191348

Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis.

I Kobayashi, M Ziff.   

Abstract

The junction between pannus and cartilage was examined in the rheumatoid joint. Three types of cartilage-pannus junction were observed. In one, proliferating small blood vessels, surrounded by highly cellular infiltrates, penetrated deeply into the cartilage. Degeneration of the cartilage was observed around the cellular accumulations. In the second, phagocytic and fibroblastic cells invaded the cartilage. In the third, fibrous pannus overlay the cartilage. Lysis of cartilage by infiltrating cells appeared to be a major cause of cartilage erosion in rheumatoid arthritis.

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Year:  1975        PMID： 1191348     DOI： 10.1002/art.1780180507

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  53 in total

Review 1.  Synovial biopsy in arthritis research: five years of concerted European collaboration.

Authors:  B Bresnihan; P P Tak; P Emery; L Klareskog; F Breedveld
Journal:  Ann Rheum Dis       Date:  2000-07       Impact factor: 19.103

2.  Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA.

Authors:  T J Smeets; M C Kraan; S Galjaard; P P Youssef; M D Smith; P P Tak
Journal:  Ann Rheum Dis       Date:  2001-06       Impact factor: 19.103

3.  Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?

Authors:  D J Buttle; H Bramwell; A P Hollander
Journal:  Clin Mol Pathol       Date:  1995-08

4.  Effects of recombinant human IL-1 beta on production of prostaglandin E2, leukotriene B4, NAG, and superoxide by human synovial cells and chondrocytes.

Authors:  T Tawara; M Shingu; M Nobunaga; T Naono
Journal:  Inflammation       Date:  1991-04       Impact factor: 4.092

5.  Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

Authors:  M B Goldring; J Birkhead; L J Sandell; T Kimura; S M Krane
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

6.  Secretion of an articular cartilage proteoglycan-degrading enzyme activity by murine T lymphocytes in vitro.

Authors:  G M Kammer; A I Sapolsky; C J Malemud
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

7.  Bidirectional erosion of cartilage in the rheumatoid knee joint.

Authors:  M Bromley; H Bertfield; J M Evanson; D E Woolley
Journal:  Ann Rheum Dis       Date:  1985-10       Impact factor: 19.103

8.  Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics.

Authors:  D G Malone; S M Wahl; M Tsokos; H Cattell; J L Decker; R L Wilder
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

9.  A tissue-culture model of cartilage breakdown in rheumatoid arthritis. Quantitative aspects of proteoglycan release.

Authors:  J Steinberg; C B Sledge; J Noble; C R Stirrat
Journal:  Biochem J       Date:  1979-05-15       Impact factor: 3.857

10.  The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells.

Authors:  M Shingu; Y Nagai; T Isayama; T Naono; M Nobunaga; Y Nagai
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330
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