| Literature DB >> 11912049 |
K Das1, V Jacob, J M Bouquegneau.
Abstract
Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver and kidney. The protein has two isoforms: MT-1 and MT-2. MT-1 binds Cu, Zn, Hg and Cd, while MT-2 only binds Zn, Hg and Cd. This suggests different metabolic functions for the two isoforms: MT-1 is mainly involved in Cu homeostasis; MT-2, which was four-fold more abundant than MT-1, detoxifies most of the accumulated cadmium.Entities:
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Year: 2002 PMID： 11912049 DOI： 10.1016/s1532-0456(02)00011-x
Source DB: PubMed Journal: Comp Biochem Physiol C Toxicol Pharmacol ISSN： 1532-0456 Impact factor: 3.228