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Literature DB >> 11911870

GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus.

Lawrence P Reagan¹, Daniel R Rosell, Stephen E Alves, Elena K Hoskin, Anthony L McCall, Maureen J Charron, Bruce S McEwen.

Abstract

Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (microglial), it appears that GLUT8 is expressed exclusively in neurons. At the cellular level, GLUT8 immunofluorescence was localized to neuronal cell bodies and the most proximal dendrites of inhibitory and excitatory neurons while GLUT3 immunofluorescence was localized to the neuropil in the hippocampus. These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus.

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Year: 2002 PMID： 11911870 DOI： 10.1016/s0006-8993(02)02308-9

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

20 in total

Review 1. Impact of postprandial glycaemia on health and prevention of disease.

Authors: E E Blaak; J-M Antoine; D Benton; I Björck; L Bozzetto; F Brouns; M Diamant; L Dye; T Hulshof; J J Holst; D J Lamport; M Laville; C L Lawton; A Meheust; A Nilson; S Normand; A A Rivellese; S Theis; S S Torekov; S Vinoy
Journal: Obes Rev Date: 2012-07-11 Impact factor: 9.213

Review 2. Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.

Authors: Simon G Patching
Journal: Mol Neurobiol Date: 2016-01-22 Impact factor: 5.590

3. Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.

Authors: Sean D Kelly; Constance S Harrell; Gretchen N Neigh
Journal: Physiol Behav Date: 2013-12-29

Review 4. GluT4: A central player in hippocampal memory and brain insulin resistance.

Authors: Ewan C McNay; Jiah Pearson-Leary
Journal: Exp Neurol Date: 2019-10-12 Impact factor: 5.330

5. Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.

Authors: Ryuta Murakami; Yoichi Chiba; Kazuhito Tsuboi; Koichi Matsumoto; Machi Kawauchi; Ryuji Fujihara; Masato Mashima; Kenji Kanenishi; Tetsuji Yamamoto; Masaki Ueno
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6. Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex.

Authors: Olga Gómez; Begoña Ballester-Lurbe; Enric Poch; José E Mesonero; José Terrado
Journal: J Anat Date: 2010-08-30 Impact factor: 2.610

7. Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [¹⁴C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation.

Authors: Gerald A Dienel; Nancy F Cruz; Louis Sokoloff; Bernard F Driscoll
Journal: Neurochem Res Date: 2015-07-04 Impact factor: 3.996

GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus.

Review 1. Impact of postprandial glycaemia on health and prevention of disease.

Review 2. Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.

3. Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.

Review 4. GluT4: A central player in hippocampal memory and brain insulin resistance.

5. Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.

6. Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex.

7. Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [¹⁴C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation.

Review 8. Effects of diabetes on brain metabolism--is brain glycogen a significant player?

9. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons.

Review 10. The SLC2 (GLUT) family of membrane transporters.

GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus.

Review 1. Impact of postprandial glycaemia on health and prevention of disease.

Review 2. Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.

3. Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.

Review 4. GluT4: A central player in hippocampal memory and brain insulin resistance.

5. Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.

6. Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex.

7. Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [14C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation.

Review 8. Effects of diabetes on brain metabolism--is brain glycogen a significant player?

9. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons.

Review 10. The SLC2 (GLUT) family of membrane transporters.

7. Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [¹⁴C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation.