| Literature DB >> 11911594 |
K Geissler1, K Schneider, U Truyen.
Abstract
Neutralizing epitopes on feline calicivirus (FCV) capsid protein were mapped using chimeric capsid proteins recombinant between two FCV isolates that do not show any cross-neutralization. The three chimeric proteins examined were expressed in murine L929 cells employing an MVA/T7 vaccinia virus expression system and inoculated into major histocompatibility complex haplotype-matched C3/HN mice. Based on the neutralizing antibody titre the neutralizing epitope(s) could be mapped to the 5' hypervariable region of the E region or potentially to the C region. The epitopes of some non-neutralizing antibodies were mapped with the same chimeric proteins to the regions B or D and F of the FCV capsid protein.Entities:
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Year: 2002 PMID： 11911594 DOI： 10.1046/j.1439-0450.2002.00529.x
Source DB: PubMed Journal: J Vet Med B Infect Dis Vet Public Health ISSN： 0931-1793