Literature DB >> 11910108

Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

Yun Shen1, Dejiang Zhou, Liyou Qiu, Xioamin Lai, Meredith Simon, Ling Shen, Zhongchen Kou, Qifan Wang, Liming Jiang, Jim Estep, Robert Hunt, Michelle Clagett, Prabhat K Sehgal, Yunyaun Li, Xuejun Zeng, Craig T Morita, Michael B Brenner, Norman L Letvin, Zheng W Chen.   

Abstract

To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.

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Year:  2002        PMID： 11910108      PMCID： PMC2872146          DOI： 10.1126/science.1068819

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

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6.  Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection.

Authors:  Yun Shen; Dejiang Zhou; Laura Chalifoux; Ling Shen; Meredith Simon; Xuejun Zeng; Xioamin Lai; Yunyuan Li; Prabhat Sehgal; Norman L Letvin; Zheng W Chen
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

7.  Divergent effect of bacillus Calmette-Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine research.

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Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

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10.  Mycobacterium bovis bacille Calmette-Guérin enhances pathogenicity of simian immunodeficiency virus infection and accelerates progression to AIDS in macaques: a role of persistent T cell activation in AIDS pathogenesis.

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Journal:  J Immunol       Date:  1999-02-15       Impact factor: 5.422
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  168 in total

1.  Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells.

Authors:  Gucheng Zeng; Crystal Y Chen; Dan Huang; Shuyu Yao; Richard C Wang; Zheng W Chen
Journal:  J Immunol       Date:  2011-06-01       Impact factor: 5.422

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Journal:  Clin Vaccine Immunol       Date:  2010-06-09

Review 3.  Role of γδ T cells in West Nile virus-induced encephalitis: friend or foe?

Authors:  Tian Wang
Journal:  J Neuroimmunol       Date:  2011-11-10       Impact factor: 3.478

Review 4.  Vgamma2Vdelta2+ T cells and anti-microbial immune responses.

Authors:  Zheng W Chen; Norman L Letvin
Journal:  Microbes Infect       Date:  2003-05       Impact factor: 2.700

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Authors:  Zheng W Chen; Norman L Letvin
Journal:  Trends Immunol       Date:  2003-04       Impact factor: 16.687

6.  Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.

Authors:  E R Mann; N E McCarthy; S T C Peake; A N Milestone; H O Al-Hassi; D Bernardo; C T Tee; J Landy; M C Pitcher; S A Cochrane; A L Hart; A J Stagg; S C Knight
Journal:  Clin Exp Immunol       Date:  2012-11       Impact factor: 4.330

7.  BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.

Authors:  Mahboob Salim; Timothy J Knowles; Alfie T Baker; Martin S Davey; Mark Jeeves; Pooja Sridhar; John Wilkie; Carrie R Willcox; Hachemi Kadri; Taher E Taher; Pierre Vantourout; Adrian Hayday; Youcef Mehellou; Fiyaz Mohammed; Benjamin E Willcox
Journal:  ACS Chem Biol       Date:  2017-09-14       Impact factor: 5.100

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Authors:  T Ulrichs; S H E Kaufmann
Journal:  Internist (Berl)       Date:  2003-11       Impact factor: 0.743

Review 9.  CD8 T cells and Mycobacterium tuberculosis infection.

Authors:  Philana Ling Lin; JoAnne L Flynn
Journal:  Semin Immunopathol       Date:  2015-04-28       Impact factor: 9.623

10.  Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.

Authors:  Liyou Qiu; Dan Huang; Cystal Y Chen; Richard Wang; Ling Shen; Yun Shen; Robert Hunt; James Estep; Barton F Haynes; William R Jacobs; Norman Letvin; George Du; Zheng W Chen
Journal:  J Infect Dis       Date:  2008-11-15       Impact factor: 5.226
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