| Literature DB >> 11909998 |
Andrew A Butler1, Shoshana Yakar, Derek LeRoith.
Abstract
Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11909998 DOI： 10.1152/nips.01351.2001
Source DB: PubMed Journal: News Physiol Sci ISSN： 0886-1714