Literature DB >> 11909993

Plasminogen activator inhibitor 1: physiological and pathophysiological roles.

Bernd R Binder1, Günter Christ, Florian Gruber, Nelly Grubic, Peter Hufnagl, Michael Krebs, Judit Mihaly, Gerald W Prager.   

Abstract

Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.

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Year:  2002        PMID： 11909993     DOI： 10.1152/nips.01369.2001

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  68 in total

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