Literature DB >> 11909733

Beta-carbolines as specific inhibitors of cyclin-dependent kinases.

Yongcheng Song1, Jian Wang, Su Fern Teng, Djohan Kesuma, Yu Deng, Jinao Duan, Jerry H Wang, Robert Zhong Qi, Mui Mui Sim.   

Abstract

Harmine (3), 7-fluoro-1-methyl beta-carboline (35) and 1-(5-methyl-imidazol-4-yl) beta-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases. The degree of aromaticity of the tricyclic ring and the positioning of substituents are important for inhibitory activity. While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.

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Year:  2002        PMID： 11909733     DOI： 10.1016/s0960-894x(02)00094-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Kinesin spindle protein inhibitors with diaryl amine scaffolds: crystal packing analysis for improved aqueous solubility.

Authors:  Tomoki Takeuchi; Shinya Oishi; Masato Kaneda; Hiroaki Ohno; Shinya Nakamura; Isao Nakanishi; Masayoshi Yamane; Jun-Ichi Sawada; Akira Asai; Nobutaka Fujii
Journal:  ACS Med Chem Lett       Date:  2014-03-10       Impact factor: 4.345

2.  Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling.

Authors:  Qin Ma; Wei Chen; Wen Chen
Journal:  Tumour Biol       Date:  2015-11-26

3.  Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Authors:  Rachid Skouta; Miki Hayano; Kenichi Shimada; Brent R Stockwell
Journal:  Bioorg Med Chem Lett       Date:  2012-06-30       Impact factor: 2.823

4.  Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis.

Authors:  Hua Wang; Huaidong Zhang; Yanling Mi; Jianhua Ju; Qi Chen; Houjin Zhang
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-09-25       Impact factor: 1.056

5.  A β-carboline derivative-based nickel(ii) complex as a potential antitumor agent: synthesis, characterization, and cytotoxicity.

Authors:  Jing-Mei Yang; Yan-Hong Zhu; Sheng Chen; Xing Lu; Yi-Ming Wu; Feng-E Ma; Liang-Ping Li; Yang Yang; Zhen-Hao Shi; Kun-Yuan Huang; Xue Hong; Ping Jiang; Yan Peng
Journal:  Medchemcomm       Date:  2017-11-24       Impact factor: 3.597

6.  An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y.

Authors:  Suresh Babu Meruva; Akula Raghunadh; Raghavendra Rao Kamaraju; U K Syam Kumar; P K Dubey
Journal:  Beilstein J Org Chem       Date:  2014-02-25       Impact factor: 2.883

7.  In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents.

Authors:  Maria L Alomar; Federico A O Rasse-Suriani; Agustina Ganuza; Verónica M Cóceres; Franco M Cabrerizo; Sergio O Angel
Journal:  BMC Res Notes       Date:  2013-05-10

8.  The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype.

Authors:  Lei Zhao; Michael Wink
Journal:  PeerJ       Date:  2013-10-01       Impact factor: 2.984

9.  The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum.

Authors:  Zaid O Ibraheem; Roslaini Abdul Majid; Sabariah Mohd Noor; Hasidah Mohd Sidek; Rusliza Basir
Journal:  Iran J Parasitol       Date:  2015 Oct-Dec       Impact factor: 1.012

10.  Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents.

Authors:  Xiao-Fei Zhang; Rong-Qin Sun; Yi-Fan Jia; Qing Chen; Rong-Fu Tu; Ke-Ke Li; Xiao-Dong Zhang; Run-Lei Du; Ri-Hui Cao
Journal:  Sci Rep       Date:  2016-09-14       Impact factor: 4.379
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