| Literature DB >> 11909725 |
Randy W Jackson1, Richard Gelinas, Ted A Baughman, Thomas Cox, J Jeffry Howbert, Kristin A Kucera, John A Latham, Fred Ramsdell, Devinder Singh, Ihab S Darwish.
Abstract
A novel series of TNF-alpha inhibitors based on a benzobicyclooctane scaffold is reported. The compounds display good potency in inhibiting TNF-alpha induced apoptosis and NF kappa B activation. Additionally, they are selective for TNF-alpha as they do not inhibit apoptosis induced by soluble Fas ligand. The compounds described here can act as leads for future medicinal chemistry efforts and may also be useful tools for elucidating the TNF-alpha signaling pathway.Entities:
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Year: 2002 PMID： 11909725 DOI： 10.1016/s0960-894x(02)00098-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823