Literature DB >> 11909722

Unprecedented overmetabolism of a porphyrinogen substrate by coproporphyrinogen oxidase.

Timothy D Lash1, Anna-Sigrid I M Keck, Ukti N Mani, Marjorie A Jones.   

Abstract

Harderoporphyrinogen-I is metabolized by avian hemolysate preparations of coproporphyrinogen oxidase to give a trivinylic product; this unprecedented 'overmetabolism' of the porphyrinogen substrate provides strong support for a proposed model of the active site of this poorly understood enzyme.

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Year:  2002        PMID: 11909722     DOI: 10.1016/s0960-894x(02)00097-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase.

Authors:  Jason R Stephenson; Julie A Stacey; Justin B Morgenthaler; Jon A Friesen; Timothy D Lash; Marjorie A Jones
Journal:  Protein Sci       Date:  2007-01-22       Impact factor: 6.725

  1 in total

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