| Literature DB >> 11909708 |
Piyasena Hewawasam1, Valentin K Gribkoff, Yadagiri Pendri, Steven I Dworetzky, Nicholas A Meanwell, Eduardo Martinez, Christopher G Boissard, Debra J Post-Munson, Joanne T Trojnacki, Krishnaswamy Yeleswaram, Lorraine M Pajor, Jay Knipe, Qi Gao, Robert Perrone, John E Starrett.
Abstract
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral resolution. Cloned maxi-K channels are opened by 1, which demonstrates a brain/plasma ratio >9 in rats.Entities:
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Year: 2002 PMID： 11909708 DOI： 10.1016/s0960-894x(02)00101-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823