Leiden research program on ageing.

Research into ageing is among the priorities of the Leiden University Medical Center. Several tight collaborations between basic and clinical departments are the basis of this program. Our focus is to identify determinants of human longevity and disease at old age with an emphasis on inflammation, atherosclerosis, and cognitive decline. To this end we enroll a large series of long-lived families for genetic screening, prospectively follow large cohorts of old people dependent on various genetic and environmental risk factors, and perform randomized controlled trials in the general population testing plausible hypotheses how interventions can maximize rewarding lifespans.