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Literature DB >> 11909545

Notch cleavage: Nicastrin helps Presenilin make the final cut.

Abstract

Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.

Entities: Gene

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Year: 2002 PMID： 11909545 DOI： 10.1016/s0960-9822(02)00749-2

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

8 in total

Review 1. Dynamic signaling for neural stem cell fate determination.

Authors: Shu Wen; Hong Li; Jia Liu
Journal: Cell Adh Migr Date: 2009-01-10 Impact factor: 3.405

2. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.

Authors: Gabriel Frampton; Monique Coufal; Huang Li; Jonathan Ramirez; Sharon DeMorrow
Journal: Exp Cell Res Date: 2010-03-25 Impact factor: 3.905

3. Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment.

Authors: Shuang Liang; Paola Galluzzo; Anna Sobol; Sylvia Skucha; Brittany Rambo; Maurizio Bocchetta
Journal: Genes Cancer Date: 2012-02

Review 4. Recent advances in the understanding of the role of the endocannabinoid system in liver diseases.

Authors: Li Huang; Matthew A Quinn; Gabriel A Frampton; Lessie Eric Golden; Sharon DeMorrow
Journal: Dig Liver Dis Date: 2010-10-08 Impact factor: 4.088

5. Zebrafish screen identifies novel compound with selective toxicity against leukemia.

Authors: Suzanne Ridges; Will L Heaton; Deepa Joshi; Henry Choi; Anna Eiring; Lance Batchelor; Priya Choudhry; Elizabeth J Manos; Hossein Sofla; Ali Sanati; Seth Welborn; Archana Agarwal; Gerald J Spangrude; Rodney R Miles; James E Cox; J Kimble Frazer; Michael Deininger; Kaveri Balan; Matthew Sigman; Markus Müschen; Tatiana Perova; Radia Johnson; Bertrand Montpellier; Cynthia J Guidos; David A Jones; Nikolaus S Trede
Journal: Blood Date: 2012-04-09 Impact factor: 22.113

Notch cleavage: Nicastrin helps Presenilin make the final cut.

Review 1. Dynamic signaling for neural stem cell fate determination.

2. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.

3. Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment.

Review 4. Recent advances in the understanding of the role of the endocannabinoid system in liver diseases.

5. Zebrafish screen identifies novel compound with selective toxicity against leukemia.

6. Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.

7. Gamma secretase inhibitors of Notch signaling.

8. Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation.