| Literature DB >> 11908979 |
Joan Malmstrøm1, Carsten Christophersen, Alejandro F Barrero, J Enrique Oltra, José Justicia, Antonio Rosales.
Abstract
From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.Entities:
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Year: 2002 PMID： 11908979 DOI： 10.1021/np0103214
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050