Literature DB >> 11908880

Physiological implications of mechanical effects of +Gz accelerations on brain structures.

Anne I Guillaume1, Daniel Osmont, Daniel Gaffié, Jean-Claude Sarron, Pierre Quandieu.   

Abstract

BACKGROUND: In certain flight configurations, fighter pilots are exposed to high Gz acceleration (G) which may induce inflight loss of consciousness (G-LOC). When acceleration is of high amplitude, and the onset rate very rapid, G-LOC can occur extremely suddenly. HYPOTHESIS: Mechanisms other than brain hypoxia could be involved, enhancing its effects. In order to study the mechanical effects induced by such accelerations on cerebral structures, we estimated the stresses imposed on cerebral tissue when the brain is exposed to +Gz acceleration forces.
METHODS: An "in vitro" experiment was performed to measure brain deformations during centrifugation. A finite element model of the brain was formulated.
RESULTS: Computations indicate that traction and shear stresses are enhanced around the tentorial notch, and that compression stresses increase at the base of the cerebral hemispheres.
CONCLUSION: The amplitude of these stresses is not sufficient to directly disturb proper nerve cell functioning. However, they could interfere with brain vessels as external surface forces, thus enhancing vessel collapse and brain ischemia.

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Year:  2002        PMID: 11908880

Source DB:  PubMed          Journal:  Aviat Space Environ Med        ISSN: 0095-6562


  2 in total

1.  Continuum modeling of a neuronal cell under blast loading.

Authors:  Antoine Jérusalem; Ming Dao
Journal:  Acta Biomater       Date:  2012-05-02       Impact factor: 8.947

2.  Protection Efficacy of the Extract of Ginkgo biloba against the Learning and Memory Damage of Rats under Repeated High Sustained +Gz Exposure.

Authors:  Liang-En Chen; Feng Wu; Andong Zhao; Hua Ge; Hao Zhan
Journal:  Evid Based Complement Alternat Med       Date:  2016-03-16       Impact factor: 2.629

  2 in total

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