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Literature DB >> 1190756

Response of yeast and mycelial phases of Histoplasma capsulatum to amphotericin B and actinomycin D.

S C Cheung, G Medoff, D Schlessinger, G S Kobayashi.

Abstract

The dimorphic fungus Histoplasma capsulatum exists in two phases: a unicellular yeast form at 37 C and a mycelium at 25 C. We have found that these two phases have selective drug susceptibilities. The mycelial form of H. capsulatum was much more susceptible to the polyene antibiotic amphotericin B than the yeast form; in contrast, the yeast form was more susceptible to the antibiotic actinomycin D. The changes in susceptibility occurred early in the transition between the two phases and permitted the transitions to be blocked by sublethal concentrations of the appropriate drugs.

Entities: Chemical Species

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Year: 1975 PMID： 1190756 PMCID： PMC429381 DOI： 10.1128/AAC.8.4.498

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation.

Authors: A FLECK; H N MUNRO
Journal: Biochim Biophys Acta Date: 1962-05-14

2. Growth of the yeastlike phase of Histoplasma capsulatum in a fluid medium.

Authors: S B SALVIN
Journal: J Bacteriol Date: 1950-02 Impact factor: 3.490

3. Two types of resistance to polyene antibiotics in Candida albicans.

Authors: C C HsuChen; D S Feingold
Journal: Nature Date: 1974-10-18 Impact factor: 49.962

Review 4. Chemistry and biology of the polyene macrolide antibiotics.

Authors: J M Hamilton-Miller
Journal: Bacteriol Rev Date: 1973-06

5. Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. I. Specificity of the membrane permeability changes induced by the polyene antibiotics.

Authors: B de Kruijff; W J Gerritsen; A Oerlemans; R A Demel; L L van Deenen
Journal: Biochim Biophys Acta Date: 1974-02-26

6. Characterization of the binding of amphotericin B to Saccharomyces cerevisiae and relationship to the antifungal effects.

Authors: J Kotler-Brajtburg; G Medoff; D Schlessinger; G S Kobayashi
Journal: Antimicrob Agents Chemother Date: 1974-12 Impact factor: 5.191

7. Ultrastructural alterations induced by amphotericin B in the plasma membrane of Epidermophyton floccosum as revealed by freeze-etch electron microscopy.

Authors: Y Nozawa; Y Kitajima; T Sekiya; Y Ito
Journal: Biochim Biophys Acta Date: 1974-10-10

8. Polyene antibiotic-sterol interactions in membranes of Acholesplasma laidlawii cells and lecithin liposomes. II. Temperature dependence of the polyene antibiotic-sterol complex formation.

Authors: B de Kruijff; W J Gerritsen; A Oerlemans; P W van Dijck; R A Demel; L L van Deenen
Journal: Biochim Biophys Acta Date: 1974-02-26

9. Porosity of the yeast cell wall and membrane.

Authors: R Scherrer; L Louden; P Gerhardt
Journal: J Bacteriol Date: 1974-05 Impact factor: 3.490

10. Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes.

Authors: B de Kruijff; R A Demel
Journal: Biochim Biophys Acta Date: 1974-02-26

4 in total

4. Quantitative Microplate-Based Growth Assay for Determination of Antifungal Susceptibility of Histoplasma capsulatum Yeasts.

Authors: Kristie D Goughenour; Joan-Miquel Balada-Llasat; Chad A Rappleye
Journal: J Clin Microbiol Date: 2015-08-05 Impact factor: 5.948